ArQule Inc. (NASDAQ:ARQL) Stock Jumps 75% In A Month, What Next?

ArQule Inc. (NASDAQ:ARQL) Stock Jumps 75% In A Month, What Next?


ArQule, Inc. (NASDAQ:ARQL) stock gained 75% over the past month after the company reported positive ARQ 531 results. The positive results showed partial remission in a leukemia patient.

ARQ 531 better than Calquence and Imbrivica

Paolo Pucci the CEO ArQule gave the update during Q42018 earnings call. Pucci indicated that an early dose escalation in the ARQ531 trial with BTK inhibitor had demonstrated a positive response. He indicated that a leukemia patient who relapsed in treatment with Calquence had shown partial response ion the ARQ531 dose escalation study.

The success of ARQ531 is a significant milestone because close to 80% of patients with chronic lymphocytic leukemia usually become resistant to drugs such as Imbruvica and Calquence. ARQ531 makes a difference in that it does not irreversibly bind to a target like BTK inhibitor Imbruvica. It appears like the anecdotal result could make a significant difference to the patient population.

Imbruvica is marketed by AbbVie (NYSE: ABBV) and Johnson & Johnson (NYSE: JNJ) as partners and they reported sales $6.2 billion last year. At least four-fifths of the patients using Imbruvica develop mutant resistance which does not stop ARQ 531.

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ArQule banks on the success of ARQ 531

This continued success is a great opportunity for ArQule who have recently seen their market cap rise to $544 million which is quite inexpensive considering its pipeline. If ARQ 531 continues to be successful without any safety concerns then ARQL stock will continue to grow. ARQ 531 is among the clinical stage drugs that the company is developing that are in the pre-commercial stage.

Although ARQ 531 has potential development of cancer drugs can be somewhat brutal. Much is not known about the drug yet which is not encouraging. Derazantinib is the most advanced asset of ArQule and there is also miransertib whose development is nearing completion but they aim a small patient population which will not provide much revenue.

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Disclosure: we hold no position in $ARQL, either long or short, and we have not been compensated for this article.

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